Envelope Gene Evolution and HIV-1 Neuropathogenesis
نویسندگان
چکیده
منابع مشابه
Envelope gene evolution and HIV-1 neuropathogenesis.
In the era of combined antiretroviral therapy (cART), HIV-associated neurocognitive disorders (HAND) account for 40 to 56% of all HIV+ cases. During the acute stage of HIV-1 infection (<6 months), the virus invades and replicates within the central nervous system (CNS). Compared to peripheral tissues, the local CNS cell population expresses distinct levels of chemokine receptors, which levels e...
متن کاملThe neuropathogenesis of HIV-1 infection.
HIV encephalitis is the common pathologic correlate of HIV-dementia (HAD). HIV-infected brain mononuclear phagocytes (MP) (macrophages and microglia) are reservoirs for persistent viral infection. When activated, MP contribute to neuronal damage. Such activated and virus-infected macrophages secrete cellular and viral factors, triggering neural destructive immune responses. Our Center's laborat...
متن کاملMononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection.
Human immunodeficiency virus type 1 (HIV-1)-associated dementia is a neuroinflammatory brain disorder that is fueled by viral infection and immune activation of brain mononuclear phagocytes (MP; macrophages and microglia). MP serve as a reservoir for persistent viral infection, a vehicle for viral dissemination throughout the brain, and a major source of neurotoxic products that when produced i...
متن کاملHIV-1 clade-specific differences in the induction of neuropathogenesis.
Human immunodeficiency virus (HIV)-associated dementia (HAD) is common among clade B HIV-infected individuals, but less common and less severe among individuals infected with clade C HIV-1, suggesting clade-specific differences in neuropathogenicity. Although differences in neuropathogenicity have been investigated in vitro using viral proteins responsible for HAD, to date there are no virologi...
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ژورنال
عنوان ژورنال: Journal of Neuroinfectious Diseases
سال: 2015
ISSN: 2314-7326
DOI: 10.4172/2314-7326.s2-003